reck@uw.edu
he/him

Research Lab

Kraemer Lab

Research Overview

I study the molecular mechanisms underlying neurodegeneration in a variety of age-related neurodegenerative disease using several model systems. I use the genetically tractable nematode worm C. elegans to model several age-related neurodegenerative diseases including Alzheimer’s disease, FTLD, and ALS. Through various genetic techniques, I identify novel modifiers of tau and TDP-43 neurodegenerative phenotypes in C. elegans and then explore the importance and translational relevance of these biological pathways in human disease using human cells, post-mortem brain tissue, and mouse models. My research is particularly focused on the ubiquitin-proteasome system, RNA metabolism, and phase-separated condensates and organelles.